The land estate of Krześlice and several adjacent villages were owned in 16th C. by one of the most famous Polish gentry families in Wielkopolska region, the Przecławscy bearing the Glaubicz coat of arms.
In 1623 the owner of Krześlice, Jan Rogaliński (a town clerk from Poznań), held a ceremonial reception in honor of prince Władysław (Sigismund III Vasa's son), who later became the king Władysław IV. The manor house must have been affluent and its surroundings in excellent order.
The first years of 18th C. saw Jan Konarski as the ruler of Krześlice. During his reign, the village and the manor house's decline started. The estate was later taken over by the Białoboccy of Ogończyk clan. Antoni Białobocki (1739-1813), buried in the Wronczyn church, was followed by his eldest son, Izydor Białobocki, as the owner of Krześlice. When Izydor Białobocki died, the estate had been additionally extended by Wronczyn, Głębokie and Złotniki. Izydor's daughter, Paulina (1813-1875) married in 1837 Anastazy Radoński (1815-1881). She became the sole heiress of the estate after her mother and siblings, Eugenia and Antoni, died.
Around 1860, a neo-Gothic palace, bearing certain features of a castle, was built for Anastazy Radoński, to be extended later, around 1890. After the final conversion, the manor house took the shape of a Romantic castle, sitting in a scenic landscape park. Judging by the age of the largest trees, the park was founded before the construction of the palace.
The subsequent heir to Krześlice, Zygmunt Radoński, was forced by the Prussian colonization committee (1886-1910) to give away the estate in 1888 to count Georg von Luttichau, in return for Rzeżewo in the Kingdom of Poland.
In 1899 the owner of Krześlice was Georg von Brandis who gave the estate, before 1904, together with the Jeżyny manor farm, to his son, Bernhard. After Bernhard went bankrupt in 1930's, the estate was taken over by the Kwilecki-Potocki Bank. Part of Krześlice real estate was partitioned, and the palace was purchased by Mr Tomaszewski, an entrepreneur from Łódź. Tomaszewski's wife, Maria was entered in the land register until 1945 as the estate's owner.
During the Second World War Krześlice was managed by Germans. Interestingly, some maps dating back to 1930's and 1940's do not show Krześlice, as an army airfield was located 1.3 km from the palace. After the war, Krześlice was taken over by a production cooperative, and later, in 1950, by a state farm in Pomarzanowice. The palace gradually fell into ruin, an in 1971 the front part of the east wing collapsed. In the beginning of 1980's it was suggested to place a gardening museum in the palace, and with that in mind the first major renovation took place. Ultimately, the museum never started, and the palace became municipal property. The palace has been privately owned since 1996. The palace and the park underwent a thorough, complete renovation, whereupon a hotel with restaurant was opened.